Web host: Faye McLain, RN
|New Breakthrough Advances Our Knowledge of Immunity|
|Richard Bennett, Ph.D. Applied Life Sciences|
At a time when science is just beginning to understand how transfer factors work in the vastly complex communications of the immune system, people throughout the world are reaping the benefits of improved health and immune system function from these amazing molecules. The work of many researchers demonstrates that transfer factors educate and enhanceimmunological functions. Highlights of this work include the documentation that natural killer (NK) cell lymphocyte activity significantly increases after a single pulse of transfer factors.
What Natural Killer Cells Do
Measuring NK Cell Activity
The Results: 4Life Transfer Factor and
|The NK cell tests for the avian/bovine 4Life Transfer Factor blends and 4Life Transfer Factor Plus blends revealed the optimal blends that induced the NK cells to kill 69 and 97% of the cancer cells, respectively (Figure 1). This represents a 283 and 437% increase over baseline, or control NK cell function, where no Transfer Factor was added. To further validate the test, the lab used a positive control. In this case, the positive control was the potent physiological immune mediator called interleukin 2 or IL-2. Interleukin 2 very specifically stimulates NK cell actions and, when used in drug form, is known as a standard for some types of cancer research. In the NK cell assay, IL-2 gave an 88% increase in cell lysis. Amazingly, 4Life Transfer Factor Plus Advanced Formula outperformed the positive control and was dubbed by the researchers as the “golden interleukin.”|
|Figure 1: Cell Lysis (% of cells killed)|
| Interleukin 2 is used in medicine for certain cancer patients. It is used in the hope that it will increase NK cell function and improve outcomes. Unfortunately, IL-2 is experimental, very expensive and can have rather toxic side effects when administered to patients. Both laboratory studies and human experience show that 4Life Transfer Factor and 4Life Transfer Factor Plus are non-toxic and well tolerated by animals and people alike. More than likely, these two products work to stimulate a natural release of immune modulators like the interleukins.
In the laboratory test, the highest-performing blend also revealed some new important information. The 4Life Transfer Factor blend followed a classic dose-response curve. Simply put, this means there is a dose of the blend in this assay that provides the optimum response. A smaller dose provides a lesser response and conversely a higher dose provides no additional benefit. Most nutritional supplements as well as prescription drugs function in the classic dose-response fashion.
|4Life Transfer Factor Plus Advanced Formula|
|4Life Transfer Factor Plus Advanced Formula increased NK cell lysis 437%, that’s nearly 450%, the maximum that this particular assay can measure. Just how this combination of ingredients works is not clear, yet the components are the subject of active research by molecular immunologists.
The additional components of 4Life Transfer Factor Plus Advanced Formula may account for the greater response over IL-2. The plant-based complex polysaccharides, like mannins and glucans, have the ability to interact with special receptors on other immune system cells. The macrophage and antigen processing cells (APC) activate in the presence of these plant materials. They appear to these cells as if they are products of bacteria or yeast. The interaction causes further release of stimulating cytokines. Thus, the two sources of stimulation synergize to give the high NK cell functions.
This type of immune stimulation is desirable, as it now appears from recent studies that a stimulated immune system is a high-functioning and balanced immune system. The concept of balance has great implication for regulation of immune functions that have gone astray.
Figure 2 is a stylized time line of immune responses to a viral infection. In a matter of one day after a new viral infection, the cytokines are in action and soon thereafter, the NK cell activity increases and peaks. At this peak, the total viral load plateaus. This plateau is due to the action of the NK cells killing the infected cells and stopping replication of the virus.
It is now clear that early and effective NK cell function is critical and determines the outcome and duration of an illness.
Figure 2: Time Line of Immune Response
Source: Nick Holmes, Ph.D., Immunology Division, Department of Pathology, University of Cambridge
|Supplementing immune function and vigilance is now possible at a level unknown less than a decade ago. The paradigm shifts, as we have the ability to move the NK cell peak activity from hours to days earlier. The amazing implication is that with improved NK function, infection without illness is possible as is tumor recognition and destruction before the tumor becomes recognized as disease.
The opportunity to prevent illness has been rather illusive, except for the application of a few vaccines. The ability to safely and inexpensively improve immune function makes this hope no longer illusive. Prevention is indeed the key and available to everyone through transfer factor.
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